The Basis Of Toxicity Testing
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The Basis of Toxicity Testing
This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies. Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.
Toxicity Testing for Assessment of Environmental Agents
Author: National Research Council
language: en
Publisher: National Academies Press
Release Date: 2006-05-07
Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.
Lu's Basic Toxicology
Continuing a long tradition, Lu‘s Basic Toxicology, Seventh Edition, provides guidance on principles of toxicology and testing procedures for toxicities as well as a concise yet detailed mechanism of both target organ and non-target organ toxicities. The book also addresses the toxic effects of chemicals and risk assessment, giving students and practicing toxicologists, the tools to enhance their practice. This edition includes new chapters on Systems Toxicology, Chemicals and Children, Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as other chapters in the book. Separate subject and chemical indexes make this a useful, quick shelf reference.