Frontiers Of Biostatistical Methods And Applications In Clinical Oncology
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Frontiers of Biostatistical Methods and Applications in Clinical Oncology
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
Soft Computing Techniques in Engineering, Health, Mathematical and Social Sciences
Soft computing techniques are no longer limited to the arena of computer science. The discipline has an exponentially growing demand in other branches of science and engineering and even into health and social science. This book contains theory and applications of soft computing in engineering, health, and social and applied sciences. Different soft computing techniques such as artificial neural networks, fuzzy systems, evolutionary algorithms and hybrid systems are discussed. It also contains important chapters in machine learning and clustering. This book presents a survey of the existing knowledge and also the current state of art development through original new contributions from the researchers. This book may be used as a one-stop reference book for a broad range of readers worldwide interested in soft computing. In each chapter, the preliminaries have been presented first and then the advanced discussion takes place. Learners and researchers from a wide variety of backgrounds will find several useful tools and techniques to develop their soft computing skills. This book is meant for graduate students, faculty and researchers willing to expand their knowledge in any branch of soft computing. The readers of this book will require minimum prerequisites of undergraduate studies in computation and mathematics.
Neuroimaging
Author: Sanja Josef Golubic
language: en
Publisher: BoD – Books on Demand
Release Date: 2019-04-03
Neuroimaging provides a valuable noninvasive window into the human neural system and is used in fundamental and clinical research. Imaging techniques are essential for understanding spontaneous neural activity and brain mechanisms engaged in the processing of external inputs, memory formation, and cognition. Modern imaging modalities make it possible to visualize memory processes within the brain and to create images of its structure and function. Scientists and technologists are joining forces to pave the way for improving imaging technologies and methods, data analysis, and the application of imaging to investigate the wide spectra of neurological diseases, neuropsychological disorders, and aging. Imaging techniques are essential for the identification of biological markers of the earliest stages of neurodiseases and the development of new therapies. This book intends to provide the reader with a short overview of the current achievements in the state-of-the-art imaging modality methods, their highlights, and limitations in neuroscience research and clinical applications. The current state of in-vivo neuroimaging methods in the context of the understanding and diagnosis of mental disorders and relation to the mind is also discussed in a modern compact format, featuring the latest and most relevant research results.