Exploration And Analysis Of Dna Microarray And Protein Array Data
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Exploration and Analysis of DNA Microarray and Protein Array Data
Author: Dhammika Amaratunga
language: en
Publisher: John Wiley & Sons
Release Date: 2009-09-25
A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage. Highlights of the text include: A review of basic molecular biology, followed by an introduction to microarrays and their preparation Chapters on processing scanned images and preprocessing microarray data Methods for identifying differentially expressed genes in comparative microarray experiments Discussions of gene and sample clustering and class prediction Extension of analysis methods to protein array data Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors’ Web site make this important text a valuable resource for both students and professionals in the field.
Exploration and Analysis of DNA Microarray and Other High-Dimensional Data
Author: Dhammika Amaratunga
language: en
Publisher: John Wiley & Sons
Release Date: 2014-01-27
Praise for the First Edition “...extremely well written...a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.
Univariate Discrete Distributions
Author: Norman L. Johnson
language: en
Publisher: John Wiley & Sons
Release Date: 2005-08-30
This Set Contains: Continuous Multivariate Distributions, Volume 1, Models and Applications, 2nd Edition by Samuel Kotz, N. Balakrishnan and Normal L. Johnson Continuous Univariate Distributions, Volume 1, 2nd Edition by Samuel Kotz, N. Balakrishnan and Normal L. Johnson Continuous Univariate Distributions, Volume 2, 2nd Edition by Samuel Kotz, N. Balakrishnan and Normal L. Johnson Discrete Multivariate Distributions by Samuel Kotz, N. Balakrishnan and Normal L. Johnson Univariate Discrete Distributions, 3rd Edition by Samuel Kotz, N. Balakrishnan and Normal L. Johnson Discover the latest advances in discrete distributions theory The Third Edition of the critically acclaimed Univariate Discrete Distributions provides a self-contained, systematic treatment of the theory, derivation, and application of probability distributions for count data. Generalized zeta-function and q-series distributions have been added and are covered in detail. New families of distributions, including Lagrangian-type distributions, are integrated into this thoroughly revised and updated text. Additional applications of univariate discrete distributions are explored to demonstrate the flexibility of this powerful method. A thorough survey of recent statistical literature draws attention to many new distributions and results for the classical distributions. Approximately 450 new references along with several new sections are introduced to reflect the current literature and knowledge of discrete distributions. Beginning with mathematical, probability, and statistical fundamentals, the authors provide clear coverage of the key topics in the field, including: Families of discrete distributions Binomial distribution Poisson distribution Negative binomial distribution Hypergeometric distributions Logarithmic and Lagrangian distributions Mixture distributions Stopped-sum distributions Matching, occupancy, runs, and q-series distributions Parametric regression models and miscellanea Emphasis continues to be placed on the increasing relevance of Bayesian inference to discrete distribution, especially with regard to the binomial and Poisson distributions. New derivations of discrete distributions via stochastic processes and random walks are introduced without unnecessarily complex discussions of stochastic processes. Throughout the Third Edition, extensive information has been added to reflect the new role of computer-based applications. With its thorough coverage and balanced presentation of theory and application, this is an excellent and essential reference for statisticians and mathematicians.