Applied Statistics For Network Biology
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Applied Statistics for Network Biology
The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.
Applied Statistics in Agricultural, Biological, and Environmental Sciences
Better experimental design and statistical analysis make for more robust science. A thorough understanding of modern statistical methods can mean the difference between discovering and missing crucial results and conclusions in your research, and can shape the course of your entire research career. With Applied Statistics, Barry Glaz and Kathleen M. Yeater have worked with a team of expert authors to create a comprehensive text for graduate students and practicing scientists in the agricultural, biological, and environmental sciences. The contributors cover fundamental concepts and methodologies of experimental design and analysis, and also delve into advanced statistical topics, all explored by analyzing real agronomic data with practical and creative approaches using available software tools. IN PRESS! This book is being published according to the “Just Published” model, with more chapters to be published online as they are completed.
Discriminative Pattern Discovery on Biological Networks
This work provides a review of biological networks as a model for analysis, presenting and discussing a number of illuminating analyses. Biological networks are an effective model for providing insights about biological mechanisms. Networks with different characteristics are employed for representing different scenarios. This powerful model allows analysts to perform many kinds of analyses which can be mined to provide interesting information about underlying biological behaviors. The text also covers techniques for discovering exceptional patterns, such as a pattern accounting for local similarities and also collaborative effects involving interactions between multiple actors (for example genes). Among these exceptional patterns, of particular interest are discriminative patterns, namely those which are able to discriminate between two input populations (for example healthy/unhealthy samples). In addition, the work includes a discussion on the most recent proposal on discovering discriminative patterns, in which there is a labeled network for each sample, resulting in a database of networks representing a sample set. This enables the analyst to achieve a much finer analysis than with traditional techniques, which are only able to consider an aggregated network of each population.