What Is The Function Of The Cytosol
Download What Is The Function Of The Cytosol PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get What Is The Function Of The Cytosol book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages.
The Role of Cytosolic Sensors in Host Defense to Intracellular Pathogens
Author: Sergio C. Oliveira
language: en
Publisher: Frontiers Media SA
Release Date: 2024-11-07
Innate immunity is the first arm of the immune system to be triggered in host defense against intracellular pathogens. Some pathogens during evolution have developed stealthy strategies to bypass innate surface receptors but when they reach host cell cytosol they are recognized by cytosolic receptors. Professional phagocytes, such as macrophages, neutrophils, or dendritic cells, have the specialized ability to internalize pathogens into membrane-bound compartments, termed phagosomes. Additionally, pathogen phagocytosis effectively guarantees the concentrated delivery of pathogen-associated molecular patterns (PAMPs) inside cells. Some pathogens can exit phagosomes and survive and replicate in the cytosolic space. Several pattern recognition receptors (PRR) have been described over the years. A diverse repertoire of PRRs exists, localized freely in the cytosol or associated with or integrated into cytoplasmic membranes, to detect these organisms. Among these intracellular sensors, several molecules have been identified such as cGAS/STING pathway, the inflammasome platforms (eg: NLRP3, NLRC4, AIM2), caspase-11/4/5, RIG-I, among others. Host cell activation through these receptors leads to cell signaling pathways resulting in inflammatory and anti-inflammatory reactions.
CSIR NET Life Science - Unit 2 - Molecular Biology of the Cell
Author: Mr. Rohit Manglik
language: en
Publisher: EduGorilla Publication
Release Date: 2024-07-03
EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels.
Sports Science Handbook: I-Z
Author: Simon P. R. Jenkins
language: en
Publisher: multi-science publishing
Release Date: 2005
A valuable reference source for professionals and academics in this field, this is an encyclopedia-dictionary of the many scientific and technical terms now encountered in kinesiology and exercise science.