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Genomic Applications in Pathology

The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.
25 Essential Windows Home Server Projects

25 Essential Windows Home Server Projects is We Got Served's must-have guide to getting the most from Microsoft's Windows Home Server platform. Written for both Windows Home Server v1 and WHS 2011 users, 25 Essential Windows Home Server Projects is the product of months of research into thousands of We Got Served features, product reviews, reader comments and forum posts to select and then create a series of 25 comprehensive, but easy to follow project walkthroughs for the popular home server operating system. Written by trusted home server experts Terry Walsh and Jim Clark, 25 Essential Windows Home Server Projects is the perfect next step for anyone who has mastered the basics of working with Windows Home Server and is seeking to do more with the product. Illustrated with hundreds of screenshots, the eBook walks through topics such as CD, DVD and Blu-ray ripping, creation of media libraries, automatic metadata collation and management, Windows Home Server support for Bittorrent and SABnzbd download clients, media streaming to remote devices, TV recording and archiving, remote backup, smartphone/tablet integration and much more. Spread over 650 A4 pages the full list of projects for WHS v1 & 2011 novices and experts alike includes: Run a Windows Home Server Application as a Service Create a Windows Home Server Powered DVR Use Windows Home Server as a File Downloader with SABnzbd Add Print Server Features to Windows Home Server Share Your Printer With Devices Across the Network Install a BitTorrent Client Install PHP and MySQL on Windows Home Server Install a Wordpress Blog on Windows Home Server Stream Music and Video Remotely to SmartPhone, Tablets or Computers Create a Windows Home Server Wiki Install a Forum on Windows Home Server Manage Your Music Metadata View Your Home Server's Files and Folders on Tablets and Smartphones Stream Video From Windows Home Server to Apple TV Backup Your Files Remotely to Windows Home Server Using VPN Build a Kick Ass Home Server From Scratch Stream Media Effortlessly to Xbox 360 and PlayStation 3 Automatically Collate and Manage Movie and TV Metadata Upgrade Remote Access to Manage Windows PCs and Macs from Tablets and Smartphones Rip CDs the Easy Way Create a Movie Library From DVD and Blu-ray Disc Manage Your Home Server Movie Library From PC & Tablet Manage and Record Video From Network Surveillance Cameras Protect Your Home Server With an Anti-Virus Agent Install Your Own Mail Server on Windows Home Server Each project includes sections for Windows Home Server v1 and WHS 2011, so all 25 projects can be completed on either platform. Whether you're a new Windows Home Server 2011 user, or a long-time Windows Home Server v1 owner who "set and forgot" a long time ago, 25 Essential Windows Home Server Projects will give you fresh ideas, inspiration and guidance to create the digital home hub you always dreamed was possible.