Vitamin Sea
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Vitamin C
The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due to factors such as smoking, occur much more frequently than does dietary vitamin C deficiency today.It is now known that low blood vitamin C levels are associated with histaminemia (high blood histamine levels), and also that ascorbate-responsive histaminemia is common in apparently healthy people. High blood histamine levels are believed to cause small hemorrhages within the inner walls of the blood vessels and these may lead to the deposition of cholesterol, as an aberrant form of wound healing. Ascorbic acid not only reduces blood histamine levels, but also aids the conversion of cholesterol to bile acids in the liver. The clinical pathological and chemical changes observed in ascorbic acid deficiency are discussed in detail. Several diseases and disorders associated with low blood vitamin C levels are also described. Possible toxic effects resulting from the oxidation of ascorbic acid are noted, and reasons for the use of D-catechin or other chelating fiber to prevent or minimize the release of ascorbate-free radical are detailed. An excellent reference for physicians, nutritionists and other scientists
Vitamin C
Author: M B Davies
language: en
Publisher: Royal Society of Chemistry
Release Date: 2007-10-31
Vitamin C is the first book to cover the history, chemistry, biochemistry, and medical importance of vitamin C and is the first to provide an in-depth, interdisciplinary study of this essential and fascinating compound. The book provides a comprehensive and systematic account of the vitamin C story, fully surveying the history of scurvy and how its cure led to the suggestion, discovery, and isolation of the vitamin, later named L-ascorbic acid. It describes in detail the vitamin's structure determination, synthesis and manufacture, and its oxidation products, derivatives and related compounds. Its key biochemical roles are fully categorized and explained, and the medical importance of the vitamin, including the recent use of so-called megadoses, is thoroughly discussed. Vitamin C will be of interest to a very wide readership and will provide useful background information and inspiration for students at various levels. It will also be relevant to the interested chemist or lay person, as well as those carrying out research in this area.
Vitamin C
Author: Stephen M. Sagar
language: en
Publisher: Rowman & Littlefield
Release Date: 2022-08-15
Vitamin C: A 500-Year Scientific Biography from Scurvy to Pseudoscience is the compelling story of the history and science behind vitamin C. Vitamin C begins with scurvy, which afflicted Europe for four hundred years and killed millions. The reasons that a disease whose cure was known from the outset persisted over that time are at once baffling and familiar, and these trials eventually lead to invention of the science of epidemiology. Author Stephen M. Sagar MD then chronicles the discovery of vitamins at the beginning of the twentieth century, a story that encapsulates the rise of a scientific approach to nutrition but with surprising twists and turns. As vitamin science became more acquainted with the mainstream, scientist Linus Pauling reached new heights of fame and influence by popularizing the practice of taking megadoses of vitamin C to prevent colds – a claim that was not necessarily backed by data. This kickstarted the growth of the $40 billion vitamin and supplement industry, which has since prospered all while ignoring science. This unique and engrossing narrative reveals how medical science functions in the real world and how it has changed over the centuries. Featuring swashbuckling sailors, arctic explorers, penny-pinching bureaucrats, academicians with clashing egos, and intrepid scientists working in malaria-infested jungle laboratories, the story of C is in many ways the story of how science gets done (and undone). From the trial and error of early explorers to the scientific breakthroughs made by biochemists and the birth of the modern supplement industry, this revelatory book tells the story of how cherished beliefs, self-interest, and politics often intertwine with scientific progress.