Updates On Epigenetic Regulation Of Endocrine Disorders With Polygenic Traits What Is New

Updates on Epigenetic Regulation of Endocrine Disorders with Polygenic Traits: What is New?

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Williams Textbook of Endocrinology E-Book

**Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Endocrinology/Metabolic Disease**Now fully revised and updated, Williams Textbook of Endocrinology, 15th Edition, remains your go-to reference for authoritative content on the full spectrum of adult and pediatric endocrine system disorders. World-renowned authors and editors expertly bridge the gap between basic science and clinical information, keeping you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. - Presents current information in a highly illustrated, user-friendly format for quick reference - Includes new chapters on Skeletal Regulation of Metabolism, Digitized Approaches to Diabetes Therapeutics, and MODY and Atypical Diabetes - Reflects updated approaches to transgender medicine as well as new coverage of viral infections, including COVID-19 - Covers hot topics such as personalized medicine; the latest methodologies and trends regarding cancer genomics, precision oncology, and cell biology; and updates in key areas such as adrenal dysfunction and diabetes - Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bone disorders, obesity and thyroid disease, as well as pituitary, gonadal, and adrenal disorders, and much more—all designed to help you provide optimal care to every patient - Features contributions from today's thought leaders in endocrinology - Contains a selected reading list and highlighted key references nominated by the editors