Uncertainty And Explanation In Medicine And The Health Sciences
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Uncertainty and Explanation in Medicine and the Health Sciences
This book offers a comprehensive account of how uncertainty is tackled in medicine and the health sciences. Olaf Dammann explores recent accounts of medicine as ineffective and suggests that the impression that medicine does not achieve its goal is, at least in part, due to the aleatoric (natural) uncertainty of biomedical processes and the subsequent epistemic (cognitive) uncertainty of those who desire solid information about such processes. Dammann shows how concepts like inference, explanation, and causometry help mitigate this disconnect. He points toward the possibility that some of the statistically rigid and formalized approaches (such as the randomized controlled trial as the gold standard for the justification of medical interventions) might better be replaced by approaches that emphasize the coherence of evidence and the people’s needs for helpful health interventions (auxiliarianism).
Uncertainty in Medicine
Introduction : The Challenge of Uncertainty in Medicine -- The Nature and Etiology of Uncertainty -- The Anatomy of Uncertainty -- The Natural History of Uncertainty -- The Management of Uncertainty -- A Way Forward : Systematizing Uncertainty Tolerance.
Uncertainty in Pharmacology
This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.