Ubiquitination In Immune System And Immune Response
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Ubiquitination in Immune System and Immune Response
Ubiquitination is a major protein post-translational modification, which is involved in many aspects of cellular procedure. The functions of ubiquitination in immune system and immune response have been intensively studied. This book aims to introduce the latest and crucial achievements, along with the fundamental principles of ubiquitination and immune responses. It covers the proteomic aspects of ubiquitination, the function of ubiquitin in innate and adoptive immunity, the development of immune cells, and the metabolism. The active researchers in this field are invited to contribute the chapters. This book is suitable for graduate students, researchers and readers who are interested in this field. It will provide readers with comprehensive insight into how ubiquitination functions in different aspects of immune system.
How Salmonella infection can inform on mechanisms of immune function and homeostasis
Author: Constantino López-Macías
language: en
Publisher: Frontiers Media SA
Release Date: 2016-04-12
The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinical signs caused by infectious agents. Therefore, this is unlikely to reflect the impact more complex host-pathogen interactions can have on the host, nor the diversity in how immunity is regulated. Humans develop immune responses in the context of the periodic exposure to multiple pathogens and vaccines over a life-time. These are likely to have a long-lasting effect on who and what we are and how we respond to further antigen challenge. Therefore, studies on how infection influences immune homeostasis and how the development of responses to a pathogen reflects what is known on immune regulation will be informative on how we can translate findings from our standard models into treatments usable in humans.
One organism allows us to do just this. Bacteria of the genus Salmonella are devastating human pathogens. Nevertheless, many aspects of the diseases they cause can be successfully modelled in murine systems so that the infection is either resolving or non-resolving. This has the advantage of allowing the long-term impact of infection on immune function to be assessed. We propose to welcome key workers to write about their research that examine the consequence of Salmonella infection on the host and the elements of the bacterium that contribute to this.
Molecular Biology of SARS-CoV-2
Author: William A. Haseltine
language: en
Publisher: Lippincott Williams & Wilkins
Release Date: 2024-06-18
Offering a thorough, accessible overview of the basic science and clinical data regarding the virus that causes COVID-19, Molecular Biology of SARS-CoV-2 is an excellent resource for researchers, clinical scientists, physicians, and students. This volume offers in-depth, extended content that originated with Drs. Roberto Patarca’s and William A. Haseltine’s chapter in The COVID-19 Textbook, edited by Dr. Haseltine and Dr. Patarca. The greatly expanded material in this text provides a much-needed primer in this complex area.