Translational Neuropsychopharmacology
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Translational Neuropsychopharmacology
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
An Interdisciplinary Approach to Aging, Biohacking and Technology
An Interdisciplinary Approach to Aging, Biohacking and Technology focuses on a broad range of issues that cover everything from the most basic ways technology and biohacking influence people’s everyday lives to concerns about equity, globalization and how we humans produce, consume and are consumed by our technologies. This edited collection looks at the intersection between technology and aging, addressing the ways in which technology affects individuals, groups, local communities and entire populations. Contributions from a range of disciplines including sociology, philosophy, communications, medicine and religion provide interdisciplinary perspectives, addressing questions such as ‘What is the impact of technology on adult bodies, our well-being and our safety?’ The book explores risks such as surveillance technology, body modification and the Internet as well as issues in the aging journey such as the body and its modification; communication, privacy and surveillance; gerontechnology and aging in place. Critically examining the journey of ageing and exploring techniques such as biohacking, this book is for students studying aging and technology, including courses such as psychology, sociology, philosophy, cultural studies, health studies and gerontology. It will also be of interest to scholars who are curious about an interdisciplinary approach to age and technology.
Toxicity and Autophagy in Neurodegenerative Disorders
Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.