Towards Precision Medicine For Immune Mediated Disorders Advances In Using Big Data And Artificial Intelligence To Understand Heterogeneity In Inflammatory Responses
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Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses
Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Community Series in Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses, volume II
The ability to understand the underlying mechanisms that drive the heterogeneity in inflammatory responses among patients suffering from immune-mediated conditions is critical. The nature of the immune mechanism ranges from the degree of immune cell activation, to the HLA genotypes, and the intensity of responses of target tissues to cytokines. High throughput experiments have generated significant information for us to facilitate the identification of disease-associated components for different complex immune-mediated conditions (e.g. psoriasis, lupus, rheumatoid arthritis, inflammatory bowel diseases), and the advances in biotechnologies and efficiency in computational resources have further promised cost-effective opportunities to simultaneously study the different aspects in the basic and translational domains of these human diseases. The critical questions we face are to provide efficient inference to integrate these datasets, and translate what we have learned from the disease-associated components to understand the heterogeneity (e.g. ethnic, gender, genetic differences) in disease manifestation and prognosis of these immune-mediated conditions. Translating and integrating big data to understand the intrinsic factors that shape the different unique natures of inflammation processes require an efficient and flexible framework to incorporate signatures of different types.
Rheumatology E-Book
Author: Marc C. Hochberg
language: en
Publisher: Elsevier Health Sciences
Release Date: 2022-07-29
Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via [email protected].