Theory Of Phase Transitions In Polypeptides And Proteins
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Theory of Phase Transitions in Polypeptides and Proteins
Author: Alexander V. Yakubovich
language: en
Publisher: Springer Science & Business Media
Release Date: 2011-09-01
There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
Peptide and Protein Drug Analysis
Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
Mathematical Physics - Proceedings Of The Xi Regional Conference
Since 1984, a series of regional conferences on mathematical physics has been organized by physicists from Iran, Pakistan and Turkey to promote the research in mathematical and theoretical physics in the region. This volume, which derives from the XI Regional Conference on Mathematical Physics, comprises 8 review and 44 research articles on the most significant topics in mathematical and theoretical physics such as astrophysics and cosmology, conformal field theory, high energy physics, general relativity and plasma physics.The review articles are comprehensive and self-contained and report on the most important developments in the corresponding subjects. Each review article provides a complete list of references, which is especially useful for graduate students who are just starting their research activities; even ambitious undergraduates in physics can use these review papers as useful background material to go further into the subject and explore the research literature. They are contributed by prominent senior scientists: M Moniez (Laboratoire de l'Accelerateur Lineare, France) and V Sahni (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) in Astrophysics and Cosmology, W Nahm (Dublin Institute for Advanced Studies (DIAS), Ireland) in Conformal Field Theory, J Lukierski (University of Wroclaw, Poland) in Mathematical Physics, Riazuddin and Fayyazuddin (Quaid-i-Azam University, Pakistan) in High Energy Physics, N Dadhich (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) and A Qadir (National University of Science and Technology, Pakistan) in General Relativity, and N Tsintsadze (Tbilisi State University, Georgia) in Plasma Physics.