The Prot G
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Dynamics and the Problem of Recognition in Biological Macromolecules
Author: Oleg Jardetzky
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.
Biopharmaceutical Production Technology, 2 Volume Set
Author: Ganapathy Subramanian
language: en
Publisher: John Wiley & Sons
Release Date: 2012-08-20
Systematically addressing the key steps and challenges along the biopharmaceutical production process, this two volume handbook provides key knowledge for medium to large scale producers of biopharmaceuticals. The volumes are divided into six major parts, on upstream technologies, protein recovery, process development, analytical technologies, quality control, and an outlook section that addresses new and emerging technologies, such as single-use processes and integrated process design. With contributions by some 40 experts from academia, as well as small and large biopharmaceutical companies, this unique handbook is full of valuable first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.
The Complete Guide to Sports Nutrition (9th Edition)
The Complete Guide to Sports Nutrition is the definitive practical handbook for anyone wanting a performance advantage. What you eat and drink are important considerations when it comes to maximising your sports performance. Whether you are a professional or amateur athlete, or just enjoy regular workouts, well-chosen nutrition strategies can enhance your performance and recovery after exercise. This ninth edition includes accessible guidance on the following topics: - Maximising endurance, strength, performance and recovery - How to calculate your optimal energy, carbohydrate and protein requirements - Advice on improving body composition - The most popular sports supplements - Relative energy deficiency in sport (RED-S) and eating disorders - Hydration strategies to prevent hypohydration and overhydration - Specific advice for masters athletes, young athletes and plant-based athletes - Nutrition strategies to prepare for competition This fully updated and revised edition incorporates the latest cutting-edge research and provides all the tools to help you reach your performance goals.