The Orexin System Basic Science And Role In Sleep Pathology
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The Orexin System. Basic Science and Role in Sleep Pathology
Author: M.A. Steiner
language: en
Publisher: Karger Medical and Scientific Publishers
Release Date: 2021-05-28
The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.
Atlas of Clinical Sleep Medicine E-Book
Author: Meir H. Kryger
language: en
Publisher: Elsevier Health Sciences
Release Date: 2022-12-14
Easy to read and richly illustrated, Atlas of Clinical Sleep Medicine, 3rd Edition, provides the tools you need to accurately diagnose and treat the full range of adult and pediatric sleep disorders. Dr. Meir H. Kryger and a team of expert contributing authors detail the physiologic, clinical, morphologic, and investigational aspects of the sleep disorders you encounter in everyday practice—enhanced by high-quality images throughout. This highly regarded, award-winning atlas is an ideal resource for sleep practitioners and technicians in the lab, as well as an effective review for certification and recertification. - Features a thoroughly illustrated, reader-friendly format that highlights key details, helping you interpret the visual manifestations of your patients' sleep disorders so you can manage them most effectively. - Contains the most up-to-date drug therapy with information about the latest drugs available as well as those in clinical trials. - Provides greater coverage of pediatric and adolescent disorders, including behavioral insomnia, new medication options, and multiple sleep latency testing (MSLT) specific to children. - Includes current AASM scoring guidelines and diagnostic criteria. - Presents correlations between normal and abnormal sleep relative to other health issues such as stroke and heart failure. - Illustrates the physiology of sleep with full-color images (many are new!) and correlates the physiology with the relevant findings. - Provides numerous resources online, including more than 80 patient interview and sleep lab videos and 200+ polysomnogram fragments.
Pharmacological Advances in Central Nervous System Stimulants
Pharmacological Advances in Central Nervous System Stimulants, Volume 99 in the Mechanisms, Therapeutic Uses, and Abuse of Stimulants series, showcases recent pharmacological progress investigating both therapeutic (ADHD, binge-eating and narcolepsy) and abuse aspects of a number of stimulants, some of which are long-standing (amphetamines, cocaine and nicotine) while others are emerging (cathinones). Specific chapters in this new release include Transgenerational Epigenetic Inheritance of Phenotypes Associated with Parental Exposure to Drugs of Abuse, Dysregulation Of Brain Cholesterol Homeostasis by Psychostimulants, Modeling Methamphetamine Use Disorder in Mammals: Sex Differences in Behavioral Consequences and Gene Expression, and much more.Additional sections focus on Second Generation Stimulants – Pharmacological and Clinical Advances in The Treatment of ADHD And Binge-eating disorder, Pharmacology Of Stimulant – Opioid Co-Use, Role Of Age and Sex in Determining the Risk For Adverse Consequences Following Exposure To Amphetamines, Modafinil, An Atypical CNS Stimulant, Modulators Of Nicotine Reward-Related and Reinforcement-Related Behaviors, Methamphetamine Effects on Peripheral Immune System, Post-Translational Mechanisms in Neurotransmitter Efflux, The Many Enigmas of Nicotine, Genetic Variation in The Neuregulin-Erbb Signaling Pathway And Substance Use Disorders, Pharmacology And Neurotoxicology of Synthetic Cathinones, and more. - Provides a diverse variety of stimulants, having different mechanisms of action and physiological effects - Includes both therapeutic uses and abuse aspects of stimulants - Covers both molecular mechanisms and behavioral effects of stimulants