The Elusive Magic Bullet

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The Elusive Magic Bullet

In his exciting new book, John Mann, author of the highly successful Murder, Magic, and Medicine, reveals the history of the drugs that are so commonplace today in the treatment of disease. While we can now treat so many of these illnesses, the side-effects caused by many of these treatmentscan be severe, and even more worrying - the bacteria are now becoming more resistant to the drugs (the so-called 'superbugs'). Scientists are also faced with a massive challenge in developing drugs that can effectively treat HIV, ebola, and many forms of cancer, but without the terribleside-effects of such treatments as chemotherapy or AZT - this is the quest for the 'magic bullet.' The book starts with a history of drug development, introducing us to some of the fascinating characters whose work so influenced the search for these drugs. Leading up to the present day, and theexciting advances being made within molecular biology, the book provides a lively, and fascinating introduction for non-scientists to one of the most exciting fields of activity within modern medicine.
Magic Bullets, Lost Horizons

From the day that Paul Ehrlich hailed his newly discovered treatment for syphilis as the magic bullet, antibiotics have transformed medical practice. They are considered one of the miracle drugs of the 20th century. However, the massive and increasing misuse of these agents is More...causing a problem of resistance that may prove to be one of the greatest threats to health in the 21st century. Magic Bullets, Lost Horizons aims to put some of the media sensationalism into perspective. It examines not only the development of modern antibiotics but also the obstacles faced during application of the drugs and their expected efficacy in the future.
The Lock and Key of Medicine

Author: Lara V. Marks
language: en
Publisher: Yale University Press
Release Date: 2015-06-28
This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.