Testosterone Transformation
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Hormones
Author: Etienne-Emile Baulieu (ed)
language: en
Publisher: Springer Science & Business Media
Release Date: 1990-11-30
Endocrinology is a field in which enormous advances have been made in the last decade; the rate of discovery of new hormones, hormone-like molecules, receptors, and mechanisms of action is continually advancing. The development of techniques in immunology and molecular biology has led to the possibility of describing in detail the gene structure of many of the compounds involved in hormonal systems. Remarkable homology has been shown between oncogene products and various components of the endocrine network, leading to the asser tion that deregulation of hormonal function is involved in the generation and/or development of cancer. We now know that the central nervous system is both a target and a production site of many hormonal products, and that hormones, neurotransmitters, growth factors and immunopeptides all act through similar mechanisms. The only second messenger known ten years ago was cAMP; today calcium, derivatives of membrane phospholipids, and protein kinases are also known to be mediators of hormone action. The very concept of hormonal systems has been expanded to include not only endocrine secretions but also para- and autohormones and their mechanisms of action; an understanding of their functions will be central to the immediate future of medicine. The discovery of hormonal molecules and endocrine interactions and the subsequent understanding of hormone related pathophysiology has led to the development of new strategies in medical treatment such as fertility control and the management of diabetes.
Foye's Principles of Medicinal Chemistry
Author: Thomas L. Lemke
language: en
Publisher: Lippincott Williams & Wilkins
Release Date: 2008
The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at thePoint.
Chemical Pathways of Metabolism
Chemical Pathways of Metabolism, Volume I focuses on the chemical steps involved in the metabolism of the major constituents of living organisms. The selection first elaborates on free energy and metabolism, enzymes in metabolic sequences, and glycolysis. Discussions focus on comparative biochemistry of glycolysis, enzymes of the glycolytic cycle, oxidative conversion of glucose to tetrose, transmethylation, and free energy and its determination. The manuscript then examines the tricarboxylic acid cycle and other pathways of carbohydrate metabolism. The text ponders on the biosynthesis of complex saccharides, including mechanisms of disaccharide formation, syntheses of branched polysaccharides, synthesis of levan from sucrose, and reversibility reactions by hydrolytic enzymes. The publication then elaborates on fat metabolism and acetoacetate formation and sterol and steroid metabolism. Topics include androgens, sterols, phospholipides or phosphatides, path of fat absorption, and theories of fatty acid breakdown and acetoacetate formation. The selection is a dependable reference for researchers interested in the chemical pathways of metabolism.