Technical Report On Toxicology And Carcinogenesis Studies Of Sodium Dichromate Dihydrate Cas No 7789 12 0 In F344 N Rats And B6c3f1 Mice Drinking Water Studies
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Technical Report on Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). Chromium VI has been shown to cause cancer when inhaled in the air. Because compounds containing chromium VI occur as contaminants in drinking water, scientists studied the effects of sodium dichromate dihydrate (SDD) in drinking water on rats and mice to identify potential toxic or cancer-related hazards. Results showed that rats exposed to SDD had carcinomas of the mouth, but none occurred in the control rats. Mice receiving SDD had greatly increased rates of cancer of the small intestine. Illus.
Statistics in Toxicology Using R
The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi
Metal Ions in Toxicology: Effects, Interactions, Interdependencies
Author: Astrid Sigel
language: en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date: 2015-07-24
Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment, for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic, and environmental biochemistry all the way through to toxicology, physiology, and medicine. Volume 8 highlights, supported by nearly 1900 references, in a comprehensive and timely manner the principles of risk assessment regarding the effects of metals on human health. It examines how metal ions and their compounds affect the pulmonary, cardiovascular, gastrointestinal (including liver), hematological, immune, and neurological systems, the kidney, skin and eyes, as well as human reproduction and development. MILS-8 terminates with the role of metal ions as endocrine disrupters, in genotoxicity, and cancer risk.