Structuring Biological Systems

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Structuring Biological Systems

Structuring Biological Systems focuses on the important components of biological systems in order to develop genetic algorithms for modeling purposes. The book considers the characteristics of biological systems from the artificial intelligence point of view, examines modeling examples of complex biological systems (such as molecular level modeling, a model of renal hemodynamics, and cognitive aspects of modeling), describes the entropy-based probability distribution for modeling of environmental and biological systems, and presents a detailed analysis of modeling cancer phenomena. Structuring Biologic Systems will benefit students and researchers interested in an interdisciplinary approach to complex problems of biological systems, as well as biologists, chemists, engineers, research physicians, and computer scientists.
Modelling Molecular Structure and Reactivity in Biological Systems

Author: Kevin Naidoo
language: en
Publisher: Royal Society of Chemistry
Release Date: 2007-10-31
Computational and theoretical tools for understanding biological processes at the molecular level is an exciting and innovative area of science. Using these methods to study the structure, dynamics and reactivity of biomacromolecules in solution, computational chemistry is becoming an essential tool, complementing the more traditional methods for structure and reactivity determination. Modelling Molecular Structure and Reactivity in Biological Systems covers three main areas in computational chemistry; structure (conformational and electronic), reactivity and design. Initial sections focus on the link between computational and spectroscopic methods in the investigation of electronic structure. The use of Free Energy calculations for the elucidation of reaction mechanisms in enzymatic systems is also discussed. Subsequent sections focus on drug design and the use of database methods to determine ADME (absorption, distribution, metabolism, excretion) properties. This book provides a complete reference on state of the art computational chemistry practised on biological systems. It is ideal for researchers in the field of computational chemistry interested in its application to biological systems.
The Bio-inspired X-Structure/Mechanism Approach for Exploring Nonlinear Benefits in Engineering

This book presents a unique approach to the design and analysis of beneficial nonlinearity, which can take an important and critical role in engineering systems and thus cannot be simply ignored in structural design, dynamic response analysis, and parameter selection. A key issue in the area is thus systematically addressed about how to analyze and design potential nonlinearities introduced to or inherent in a system, which is a must-do task in many practical applications involving vibration control, energy harvesting, sensor systems and robots, etc. This book, therefore, presents an up-to-date summary on the most recent development of a cutting-edge method for nonlinearity manipulation and employment developed in recent several years, known as the X-shaped structure or mechanism approach. The method is inspired from animal leg/limb skeletons and can provide passive low-cost high-efficiency adjustable and beneficial nonlinear stiffness (high static and ultra-low dynamic), nonlinear damping (dependent on resonant frequency and vibration excitation amplitude), and nonlinear inertia (low static and high dynamic) individually or simultaneously. The X-shaped structure or mechanism is a generic structure or mechanism representing a class of beneficial geometric nonlinearity with realizable and flexible linkage mechanism or structural design of different variants or forms (quadrilateral, diamond, polygon, K/Z/S/V/A/W-shape, or others) which all share similar geometric nonlinearity and thus similar nonlinear stiffness/damping properties, flexible in design, and easy to implement. This book systematically introduces the research background, motivation, essential bio-inspired ideas, advantages of this novel method, beneficial nonlinear properties in stiffness, damping and inertia, associated theory for analysis and design of nonlinear dynamics, potential applications and case studies, most of which have been developed ever since 2010. This is Part I of this book series, and the results in this book focus on beneficial nonlinear stiffness and damping characteristics of the fundamental X-shaped structure/mechanism and its variants, and provide an in-depth understanding of potential nonlinear properties that can be achieved through passive structural/mechanism designs via this class of X-structures or mechanisms.