Specificity Function And Development Of Nk Cells
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Specificity, Function, and Development of NK Cells
Author: Klas Kärre
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.
Specificity, Function, and Development of NK Cells
Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.
Molecular Basis of NK Cell Recognition and Function
Author: L. Moretta
language: en
Publisher: Karger Medical and Scientific Publishers
Release Date: 1996
Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.