Simple Rapid Method For The Preparation Of Isotopically Labeled Formaldehyde

Simple, Rapid Method for the Preparation of Isotopically Labeled Formaldehyde

Isotopically labeled formaldehyde (*C.sup.sctn. H.sub. 2O) is prepared from labeled methyl iodide (*C.sup.sctn. H.sub. 3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C.sup.sctn. H.sub. 2O with little or no *C isotopic dilution. The simple, efficient production of .sup. 11CH.sub. 2O is described. The use of the .sup. 11CH.sub. 2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

Nuclear Science Abstracts

NSA is a comprehensive collection of international nuclear science and technology literature for the period 1948 through 1976, pre-dating the prestigious INIS database, which began in 1970. NSA existed as a printed product (Volumes 1-33) initially, created by DOE's predecessor, the U.S. Atomic Energy Commission (AEC). NSA includes citations to scientific and technical reports from the AEC, the U.S. Energy Research and Development Administration and its contractors, plus other agencies and international organizations, universities, and industrial and research organizations. References to books, conference proceedings, papers, patents, dissertations, engineering drawings, and journal articles from worldwide sources are also included. Abstracts and full text are provided if available.

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