Semiparametric Theory And Missing Data

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Semiparametric Theory and Missing Data

Author: Anastasios Tsiatis
language: en
Publisher: Springer Science & Business Media
Release Date: 2007-01-15
Missing data arise in almost all scientific disciplines. In many cases, the treatment of missing data in an analysis is carried out in a casual and ad-hoc manner, leading, in many cases, to invalid inference and erroneous conclusions. In the past 20 years or so, there has been a serious attempt to understand the underlying issues and difficulties that come about from missing data and their impact on subsequent analysis. There has been a great deal written on the theory developed for analyzing missing data for finite-dimensional parametric models. This includes an extensive literature on likelihood-based methods and multiple imputation. More recently, there has been increasing interest in semiparametric models which, roughly speaking, are models that include both a parametric and nonparametric component. Such models are popular because estimators in such models are more robust than in traditional parametric models. The theory of missing data applied to semiparametric models is scattered throughout the literature with no thorough comprehensive treatment of the subject. This book combines much of what is known in regard to the theory of estimation for semiparametric models with missing data in an organized and comprehensive manner. It starts with the study of semiparametric methods when there are no missing data. The description of the theory of estimation for semiparametric models is at a level that is both rigorous and intuitive, relying on geometric ideas to reinforce the intuition and understanding of the theory. These methods are then applied to problems with missing, censored, and coarsened data with the goal of deriving estimators that are as robust and efficient as possible.
Applied Missing Data Analysis in the Health Sciences

Applied Missing Data Analysis in the Health Sciences A modern and practical guide to the essential concepts and ideas for analyzing data with missing observations in the field of biostatistics With an emphasis on hands-on applications, Applied Missing Data Analysis in the Health Sciences outlines the various statistical methods for the analysis of missing data. The authors acknowledge the limitations of established techniques and provide newly-developed methods with concrete applications in areas such as causal inference. Organized by types of data, chapter coverage begins with an overall introduction to the existence and limitations of missing data and continues into techniques for missing data inference, including likelihood-based, weighted GEE, multiple imputation, and Bayesian methods. The book subsequently covers cross-sectional, longitudinal, hierarchical, survival data. In addition, Applied Missing Data Analysis in the Health Sciences features: Multiple data sets that can be replicated using SAS®, Stata®, R, and WinBUGS software packages Numerous examples of case studies to illustrate real-world scenarios and demonstrate applications of discussed methodologies Detailed appendices to guide readers through the use of the presented data in various software environments Applied Missing Data Analysis in the Health Sciences is an excellent textbook for upper-undergraduate and graduate-level biostatistics courses as well as an ideal resource for health science researchers and applied statisticians.