Screeching Halt
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Screeching Halt
Forget everything you thought you knew about politics. This is Minnesota. Step into the wacky world of Minnesota politics, as magazine editor Dashmagne Grant moves from reluctant hero to star of The Tonight Show, and then on to gubernatorial candidate and national celebrity. Along the way, he falls in love twice-only to lose both women-as fate hurtles him from Minnesota to Dallas, with stops in Hollywood and the Florida Keys. All of this wouldn't be so bad if not for the moderately insane people who surround Dash. There's the clueless Minnesota governor with three last names and a political platform based on Mass Confusion. A shady best friend with a talent for picking up radio signals by grinding his teeth. And then there's the sexy super model who adores him, and an eccentric Texas billionaire who wants to make him famous. Is it any wonder Grant's normally serene life has come to a screeching halt?
Maternal Control of Development in Vertebrates
Author: Florence Louise Marlow
language: en
Publisher: Morgan & Claypool Publishers
Release Date: 2010
Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
The Mountain Is Calling
In a time where everyone is looking for the Glory of God, but few are willing to pay the price to carry such an awesome responsibility, this is a prophetic and apostolic journey captured in print that will show you what it means to take up your cross and follow Jesus. Join Apostle Kay C. Tyler on this expedition as she takes you from the palace to the desert, and up to the mountain. One day youll be caught between heaven and earth, and the next experiencing the grave. Only to be led into resurrection, and ultimately a time of glorification. Get ready! This book is not for the fainthearted as the very anointing that drips from these pages will catapult you into experiencing the journey for yourself.