Sars Cov 2 Variants B Lymphocytes And Autoreactivity

SARS-CoV-2 variants, B lymphocytes, and autoreactivity

Firestein & Kelley's Textbook of Rheumatology - E-Book

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment―including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

Long COVID and Brain Inflammation: Unravelling Mechanisms and Potential Therapies

COVID-19, an illness caused by the novel coronavirus SARS-CoV-2, has affected millions of people worldwide. Despite the virus’ primary target being the respiratory system, it has become increasingly apparent that it can also affect other organs, such as the brain. Patients with long COVID often report persistent symptoms, such as brain fog, mood changes, and dizziness, after the acute infection has resolved. These symptoms likely reflect neuroinflammation, an immune response to brain injury or infection. Research has shown that SARS-CoV-2 can cause neuroinflammation in the brain, causing persistent brain inflammation even after clearing the virus. Additionally, imaging studies have shown structural and functional changes in the brain of long COVID patients, indicating ongoing inflammation. The mechanisms underlying this link between COVID-19 and brain inflammation are still not fully understood, and research is ongoing to find effective therapies for long COVID symptoms. Understanding the mechanisms behind long COVID and neuroinflammation is crucial to developing targeted therapies that alleviate these symptoms.