Ring Nitrogen And Key Biomolecules
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Ring Nitrogen and Key Biomolecules
Author: E.G. Brown
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
The nitrogen-containing ring structures are at the hub of metabolism and include ATP, nucleic acids, many coenzymes, metabolic regulators and integrators such as adenosine and GTP, signalling compounds such as cyclic nucleotides and plant cytokinins and biochemically functional pigmets of which haemoglobin, the cytochromes and chlorophyll are examples. This important book collates and integrates current knowledge of all the biologically important N-heterocyclic compounds, covering the relationship between their chemical structures and physiological functions within this key group of compounds. Few biochemical reaction sequences do not involve one of these compounds as a substrate, product or coenzyme and a full understanding of the interrelationship between their structure and function is vital for all those woorking in the field of biochemistry. Professor Eric Brown who has a huge wealth of experience in teaching and research on these compounds has written a very comprehensible and thorough book which will be of great value for advanced students and researchers in biochemistry and those at the interfacing subject areas of chemistry, biology and pharmacology including all those employed in researching biological function within pharmaceutical companies.
Ring Nitrogen and Key Biomolecules
This reference text provides a link between N-heterocyclic chemistry and biochemistry, enabling a researcher to consult one volume to obtain the structural properties of the N-heterocyclics and the physiological processes in which they take part. N-heterocyclics include molecules of important biological significance, among them the majority of coenzymes, metabolic regulators and integrators such as adenosine and GTP, signalling compounds like the cyclic nucleotides and plant cytokinins, and biochemically functional pigments such as haemoglobin and chlorophyll. In this book the author brings up questions about the role of these components in different metabolic regulations and their biological functions. It should be of use to post-graduate students and researchers in fields such as metabolism, pharmacology, biotechnology, biochemistry, agrochemistry and general chemistry.
Copper in N-Heterocyclic Chemistry
Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. - Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds - Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals - Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail