Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition
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Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition
Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.
Insect Diapause
Author: David L. Denlinger
language: en
Publisher: Cambridge University Press
Release Date: 2022-02-03
Captures the full scope of the literature, integrating ecological and molecular mechanisms that enable insects to enter a dormant state.
Insect Pests in Tropical Forestry
"The management of tropical forest ecosystems is essential to the health of the planet. This book addresses forest insect pest problems across the world's tropics, addressing the pests' ecology, impact and possible approaches for their control. Fully updated, this second edition also includes discussions of new areas of interest including climate change, invasive species, forest health and plant clinics. This work is an indispensible resource for students, researchers and practitioners of forestry, ecology, pest management and entomology in tropical and subtropical countries."--pub. desc.