Regulation Of Intracellular Ca2 Release Channels By Ca2 And Ca2 Binding Proteins
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Regulation of Intracellular Ca2+-Release Channels by Ca2+ and Ca2+-Binding Proteins
Author: Nael Nadif Kasri
language: en
Publisher: Leuven University Press
Release Date: 2004
This is a Ph.D. dissertation. Almost everything we do is controlled by Ca2+, how we move, how our hearts beat and how our brains process information and store memories. Ca2+ is indeed a ubiquitous second messenger involved in a diversity of cellular activities such as muscular contraction, neurotransmitter release, synaptic plasticity, gene transcription, cell proliferation and apoptosis. The average cytosolic concentration of Ca2+ in resting cells ranges from 50nM to 100nM, reaching values close to 1uM when the cell is stimulated by a variety of physiological stimuli, while in the extracellular milieu this concentration is about 1mM. This large concentration gradient allows intracellular Ca2+ to work as a useful second messenger. Contents include: General Introduction, Objectives, Results, General Discussion, Summary.
Encyclopedia of Molecular Pharmacology
Author: Stefan Offermanns
language: en
Publisher: Springer Science & Business Media
Release Date: 2008-08-14
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Principles of Molecular Regulation
Author: P. Michael Conn
language: en
Publisher: Springer Science & Business Media
Release Date: 2000-07-28
With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.