Purines As Transmitter Molecules
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Purines as transmitter molecules. Electrophysiological studies on purinergic signalling in different cell systems
Author: Elisabetta Coppi
language: en
Publisher: Firenze University Press
Release Date: 2009
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells.
Molecular Biochemistry and Physiology of Helminth Neuromuscular Systems
This collection of articles, edited by D. W. Halton, is the specially commissioned supplement to the journal Parasitology, volume 113.
Bioinformatics of Genome Evolution: from Ancestral to Modern Metabolism Phylogenomics and Comparative Genomics to Understand Microbial Evolution
Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).