Patient Specific Controller For An Implantable Artificial Pancreas
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Patient-Specific Controller for an Implantable Artificial Pancreas
The thesis focuses on the control of blood glucose devices and design of implantable devices, and offers valuable insights on diabetes mellitus and related physiology and treatments. Diabetes mellitus is a widespread chronic disease in the modern world that affects millions of people around the globe. In Singapore, one in ten of the population has diabetes, and the severity of the problem has prompted the country’s prime minister to talk about the disease at the National Day Rally in 2017. Designing an artificial pancreas that can provide effective blood glucose control for individuals with diabetes is one of the most challenging engineering problems. The author reports on research into the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosages of insulin when necessary. By sensing blood glucose and injecting insulin directly into the vein, the implantable device aims to remove delays that occur with subcutaneous blood glucose sensing and insulin delivery. Preliminary in-vitro and in-vivo experimental results suggest that the implantable device for blood glucose control could be a clinically viable alternative to pancreas transplant.
Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI Approach
Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult. - Presents control-oriented modeling of the gluco-regulatory system of Type 1 diabetic patients using input-output data - Demonstrates the design of a robust insulin delivery mechanism utilizing state estimation information with parametric uncertainties and exogenous disturbance in the framework of Linear Matrix Inequality (LMI) - Introduces readers to the relevance and effectiveness of powerful nonlinear controllers for the Artificial Pancreas - Provides the first book on LMI-based nonlinear control techniques for the Artificial Pancreas
Medical Instrumentation
Provides a comprehensive overview of the basic concepts behind the application and designs of medical instrumentation This premiere reference on medical instrumentation describes the principles, applications, and design of the medical instrumentation most commonly used in hospitals. It places great emphasis on design principles so that scientists with limited background in electronics can gain enough information to design instruments that may not be commercially available. The revised edition includes new material on microcontroller-based medical instrumentation with relevant code, device design with circuit simulations and implementations, dry electrodes for electrocardiography, sleep apnea monitor, Infusion pump system, medical imaging techniques and electrical safety. Each chapter includes new problems and updated reference material that covers the latest medical technologies. Medical Instrumentation: Application and Design, Fifth Edition covers general concepts that are applicable to all instrumentation systems, including the static and dynamic characteristics of a system, the engineering design process, the commercial development and regulatory classifications, and the electrical safety, protection, codes and standards for medical devices. The readers learn about the principles behind various sensor mechanisms, the necessary amplifier and filter designs for analog signal processing, and the digital data acquisition, processing, storage and display using microcontrollers. The measurements of both cardiovascular dynamics and respiratory dynamics are discussed, as is the developing field of biosensors. The book also covers general concepts of clinical laboratory instrumentation, medical imaging, various therapeutic and prosthetic devices, and more. Emphasizes design throughout so scientists and engineers can create medical instruments Updates the coverage of modern sensor signal processing New material added to the chapter on modern microcontroller use Features revised chapters, descriptions, and references throughout Includes many new worked out examples and supports student problem-solving Offers updated, new, and expanded materials on a companion webpage Supplemented with a solutions manual containing complete solutions to all problems Medical Instrumentation: Application and Design, Fifth Edition is an excellent book for a senior to graduate-level course in biomedical engineering and will benefit other health professionals involved with the topic.