Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 491 Short Time Exposure In Vitro Test Method For Identifying I Chemicals Inducing Serious Eye Damage And Ii Chemicals Not Requiring Classification For Eye Irritation Or Serious Eye Damage


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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage


OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Author: OECD

language: en

Publisher: OECD Publishing

Release Date: 2025-06-25


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This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage


OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

Author: OECD

language: en

Publisher: OECD Publishing

Release Date: 2025-06-25


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This Test Guideline describes an in vitro procedure allowing the identification of chemicals (substances and mixtures) not requiring classification and labelling for eye irritation or serious eye damage in accordance with UN GHS.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation


OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation

Author: OECD

language: en

Publisher: OECD Publishing

Release Date: 2025-06-25


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This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties.