Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos
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OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos
The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Lignes directrices de l'OCDE pour les essais de produits chimiques, Section 2 Essai n° 250: Détection sur des embryons de poisson-zèbre transgénique tg(cyp19a1b:GFP) des perturbateurs endocriniens agissant via les récepteurs des œstrogènes (essai EASZY)
La méthode d’essai EASZY (Endocrine Active Substances using Zebrafish embrYos) est une méthode de dépistage in vivo de type mécanistique, conçue pour détecter les perturbateurs endocriniens agissant comme agonistes des récepteurs des œstrogènes (estrogen receptors, ER), en induisant l’expression de la protéine fluorescente verte (Green Fluorescent Protein, GFP) sous le contrôle du promoteur du gène cyp19a1b.
OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.