Ocular Circulation And Neovascularization
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Ocular Circulation and Neovascularization
Author: D. Benezra
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif·ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand & upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook
Retinal and Choroidal Vascular Diseases of the Eye
Retinal and Choroidal Vascular Diseases of the Eye explores a variety of retinal and choroidal vascular diseases, covering their pathogenesis, clinical features, and management strategies. The book begins with an outline of the basic features of retinal and choroidal vasculature before moving on to imaging techniques. Chapters then delve into specific diseases and abnormalities, as well as vascular diseases that are associated with systemic inflammatory diseases. The book then moves onto considering vascular diseases associated with system conditions before considering vascular tumors. Recent innovations and upcoming treatment options are also explored for the various diseases throughout the book. This comprehensive reference provides a deep dive into vascular diseases of the eye, and is a must-have reference for ophthalmologists, medical and surgical retina specialists, and researchers in related fields - Explores numerous retinal and choroidal disease entities and their pathogenic mechanisms - Features multimodal images to help illustrate and describe the disease entities - Discusses innovative treatment options for choroidal vascular diseases - Considers the latest clinical trials related to retinal and choroidal disorders, and provides key learnings
Choroidal Neovascularization
The book discusses all aspects of choroidal neovascularization (CNV), including the basics, clinical conditions associated with CNV, clinical trials related to CNV, future directions and rehabilitation. The first section covers the pathogenesis, proposed mechanisms, disease models, histopathology and electronmicroscopy. The next section explores CNV secondary to various clinical conditions, such as age-related macular degeneration (AMD), myopia, and less common conditions like choroidal osteoma. The book also covers clinical features, imaging characteristics, and treatment approaches, as well as clinical trials in CNV conditions with recent updates. Lastly, it features chapters on stem cell therapy, gene therapy, new molecules, and lasers, as well as a section on rehabilitation, which addresses home monitoring and low vision aids. This book is intended for retina specialists, retina fellows and general ophthalmologists.