Neuronal Activity In Tumor Tissue
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Neuronal Activity in Tumor Tissue
Author: Kurt S. Zänker
language: en
Publisher: Karger Medical and Scientific Publishers
Release Date: 2007-01-01
This book summarizes the current knowledge on how tumors interact with the nervous system and what impact this might have for the progression and treatment of cancer. It begins with an introduction to the organization and physiology of the nervous system, especially of the peripheral nervous system with its high degree of plasticity. Subsequent chapters discuss the interaction between peripheral nerves and tumor cells, the so-called neuro-neoplastic synapse, with regard to carcinogenesis, predictive tumor markers, tumor growth and tumor progression leading to metastasis. In this part, the concept of neoneurogenesis is postulated as a process by which the tumor regulates its own innervation through the release of neurotrophic factors, in analogy to the process of neoangiogenesis discovered three decades ago. Once nerve endings have grown into the tumor, these can release neurotransmitters which promote tumor cell migration and metastasis development. The final chapters reflect on the role of stem cells in neoneurogenesis and consider pharmacological approaches for the inhibition of neuro-neoplastic interactions as a basis for new anticancer therapies. Targeted primarily at investigators in experimental and clinical oncology, this book is also of special interest to neurobiologists as well as developmental and cell biologists.
Neuronal Activity in Tumor Tissue
Author: Kurt S. Zänker
language: en
Publisher: Karger Medical and Scientific Publishers
Release Date: 2007
This book summarizes the current knowledge on how tumors interact with the nervous system and what impact this might have for the progression and treatment of cancer. It begins with an introduction to the organization and physiology of the nervous system, especially of the peripheral nervous system with its high degree of plasticity. Subsequent chapters discuss the interaction between peripheral nerves and tumor cells, the so-called neuro-neoplastic synapse, with regard to carcinogenesis, predictive tumor markers, tumor growth and tumor progression leading to metastasis. In this part, the concept of neoneurogenesis is postulated as a process by which the tumor regulates its own innervation through the release of neurotrophic factors, in analogy to the process of neoangiogenesis discovered three decades ago. Once nerve endings have grown into the tumor, these can release neurotransmitters which promote tumor cell migration and metastasis development. The final chapters reflect on the role of stem cells in neoneurogenesis and consider pharmacological approaches for the inhibition of neuro-neoplastic interactions as a basis for new anticancer therapies. Targeted primarily at investigators in experimental and clinical oncology, this book is also of special interest to neurobiologists as well as developmental and cell biologists.
Neurobiology of Cancer
The focus of this book is to describe the current understanding of the interactions between the nervous system and cancer and the use of this information in the treatment and prevention of cancer. Author and noted researcher Boris Mravec presents a clearly written and well-illustrated monograph on this rapidly developing new field. The book begins with an exploration of the basic concepts supporting the neurobiology of cancer, discusses the ways in which the nervous system affects all the hallmarks of cancer, delves extensively into stress and cancer, covers the etiopathogenetic consequences of the neurobiology of cancer, the implications for cancer prevention and treatment, and looks at future directions in the field.