Net 4 0 Generics
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Generic Stabilizers in Actions of Simple Algebraic Groups
Author: R. M. Guralnick
language: en
Publisher: American Mathematical Society
Release Date: 2024-09-09
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Retrosynthesis in the Manufacture of Generic Drugs
Author: Pedro Paulo Santos
language: en
Publisher: John Wiley & Sons
Release Date: 2020-11-09
Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select. Each chapter in Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is dedicated to one drug, with each containing information on: worldwide sales and patent status of the Active Pharmaceutical Ingredient (API); structure analysis and general retrosynthetic strategy of the API; first reported synthesis; critical analysis of the processes which have been developed and comparison of the synthetic routes; lessons learned; reaction conditions for Schemes A to X; chemical "highlights" on key reactions used during the synthesis; and references. Drugs covered include: Gabapentin, Clopidogrel, Citalopram and Escitalopram, Sitagliptin, Ezetimibe, Montelukast, and Oseltamivir. Show how the retrosynthetic tool is used by the Pharmaceutical Industry Fills a gap for a book where retrosynthetic analysis is systematically applied to active pharmaceutical ingredients (APIs) Features analyses and methodologies that aid readers in uncovering practical synthetic routes to other drug substances, whether they be NCEs (New Chemical Entities) or generic APIs (Active Pharmaceutical Ingredients) Presents information from both the patent and academic literature for those who wish to use as a basis for further study and thought Features the use of "reaction maps" which display several synthetic processes in the same scheme, and which allow easy comparisons of different routes that give the same molecule or intermediate. A selection of these maps are available to download from: https://www.wiley.com/go/santos/retrosynthesis Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is an ideal book for researchers and advanced students in organic synthetic chemistry and process chemistry. It will also be of great benefit to practitioners in the pharmaceutical industry, particularly new starters, and those new to process chemistry.
Passive Network Synthesis: An Approach to Classification
A resurgence of interest in network synthesis in the last decade, motivated in part by the introduction of the inerter, has led to the need for a better understanding of the most economical way to realize a given passive impedance. This monograph outlines the main contributions to the field of passive network synthesis and presents new research into the enumerative approach and the classification of networks of restricted complexity. Passive Network Synthesis: An Approach to Classification serves as both an ideal introduction to the topic and a definitive treatment of the Ladenheim catalogue. In particular, the authors provide a new analysis and classification of the Ladenheim catalogue, building on recent work, to obtain an improved understanding of the structure and realization power of the class within the biquadratic positive-real functions. This book is intended for researchers in systems and control, real algebraic geometry, electrical and mechanical networks, and dynamics and vibration.