Modeling Biomaterials

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Modeling Biomaterials

The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.
Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. - Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles - Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types - Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery
Materiomics: Multiscale Mechanics of Biological Materials and Structures

Author: Markus J. Buehler
language: en
Publisher: Springer Science & Business Media
Release Date: 2013-11-18
Multiscale mechanics of hierarchical materials plays a crucial role in understanding and engineering biological and bioinspired materials and systems. The mechanical science of hierarchical tissues and cells in biological systems has recently emerged as an exciting area of research and provides enormous opportunities for innovative basic research and technological advancement. Such advances could enable us to provide engineered materials and structure with properties that resemble those of biological systems, in particular the ability to self-assemble, to self-repair, to adapt and evolve, and to provide multiple functions that can be controlled through external cues. This book presents material from leading researchers in the field of mechanical sciences of biological materials and structure, with the aim to introduce methods and applications to a wider range of engineers.