Mistletoe Extract Side Effects
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Meyler's Side Effects of Drugs 15E
Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary or pharmaceutical company. Now available online for all academic, corporate or government institution as well as individuals viaScience Direct! The online version provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organised alphabetically Completely expanded coverage of each drug - thalidomide warranted three sentences in Meyler's 14th edition, but is now a 13 page extensive monograph Clearer, systematic organization of information for easier reading including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references - Meyler's 15th edition incorporates all relevant citations from Meyler's 14th, but also includes relevant citations from previous editions of Meyler's and Side Effects of Drugs Annuals to give a historical perspective on the use and safety of drugs
New Insights in Veterinary Cancer Immunology
Author: Carlos Eduardo Fonseca-Alves
language: en
Publisher: Frontiers Media SA
Release Date: 2025-01-14
The tumour microenvironment (TME) is essential for cancer maintenance and is responsible for several antitumor characteristics, such as immune system avoidance, resistance to anticancer therapies, invasion, and metastasis. The TME is composed of several components, including fibroblasts, extracellular matrix proteins, pericytes, and immune cells. The immune cells, including T-lymphocytes, are responsible for fighting cancer cells, inducing cell death. However, cancer cells develop several mechanisms to avoid the immune system, including mutations to change the antigens originally recognised by T-cells. Tumours that can avoid the immune system, including the T-cell antitumor response, are known as nonimmunogenic tumours or “cold” tumours. The main characteristic of this tumour subtype is lack of response to immunotherapy drugs. In contrast, immunogenic, or “hot” tumours have an active T-cell antitumor response and respond well to immunotherapy. Therefore, elucidating the TME characteristics is the first step for the application in clinical practice. In recent years, there has been progress in understanding how the immune system and inflammation are associated with different cancer subtypes. In 2018, the Nobel Prize in Physiology and Medicine was awarded for the discovery of cancer therapy by the inhibition of negative immune regulation. Since then, there has been an increase in global attention directed towards the immune system and its implications for cancer therapy. Tumour progression is highly dependent of modifications in the TME, which are directly related with patient’s prognosis and present direct impacts on chemotherapy efficiency. Investigating and comprehending the TME composition during tumour progression allows new therapeutic strategies and approaches personalized to each patient. Thus, understanding its complex interactions leads to different strategies to reprogramming TME for therapeutic purposes. The main goal of this special issue is to bring together manuscripts focused on cancer immunology with a translational approach. We welcome Original Research and Review articles from investigators worldwide that will stimulate the continuing efforts to understand the interactions with tumour microenvironment, including: 1) Identification of immune cells as a prognostic factor for cancer in veterinary patients. 2) Stratification of tumour in animals according to its immunological content (hot or cold tumours) 3) Specific therapies targeting immune system components with translational potential 4) Genetic and epigenetic cancer modifications associated with the immune cells 5) Therapeutic implications of antitumor vaccines in small animals
The Encyclopedia of Women's Reproductive Cancer
Presents articles on female reproductive cancer, including symptoms, current research, and treatment options. Includes resource directories.