Miniaturized Biosensing Devices
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Miniaturized Biosensing Devices
This book presents tools and techniques for the development of miniature biosensors and their applications. The initial chapters discuss the advancements in the development of the transduction techniques, including optical, electrochemical, and piezoelectric, which are used for miniaturized biosensors. The book also reviews several technologies, such as nanotechnology, nanobiotechnology, immune-technology, DNA-technology, micro-manufacturing technology, electronic-circuit technology to increase the miniaturization and sensitivity of the biosensor platform. Subsequently, the chapters illustrate the applications of miniaturized biosensing systems in point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics, and biomedical research. Towards the end, the book discusses the advanced applications of biosensors in water quality monitoring, especially on-line detection systems and on-site detection of pesticides, heavy metals and bacteria in water. This book is an invaluable source for scientists working in biochemical engineering, bioengineering, and biomedical engineering in academia and industry.
Bacterial Sensors
Bacterial reporters are live, genetically engineered cells with promising application in bioanalytics. They contain genetic circuitry to produce a cellular sensing element, which detects the target compound and relays the detection to specific synthesis of so-called reporter proteins (the presence or activity of which is easy to quantify). Bioassays with bacterial reporters are a useful complement to chemical analytics because they measure biological responses rather than total chemical concentrations. Simple bacterial reporter assays may also replace more costly chemical methods as a first line sample analysis technique. Recent promising developments integrate bacterial reporter cells with microsystems to produce bacterial biosensors. This lecture presents an in-depth treatment of the synthetic biological design principles of bacterial reporters, the engineering of which started as simple recombinant DNA puzzles, but has now become a more rational approach of choosing and combining sensing, controlling and reporting DNA 'parts'. Several examples of existing bacterial reporter designs and their genetic circuitry will be illustrated. Besides the design principles, the lecture also focuses on the application principles of bacterial reporter assays. A variety of assay formats will be illustrated, and principles of quantification will be dealt with. In addition to this discussion, substantial reference material is supplied in various Annexes. Table of Contents: Short History of the use of Bacteria for Biosensing and Bioreporting / Genetic Engineering Concepts / Measuring with Bioreporters / Epilogue
Miniaturized Electrochemical Devices
Evidently, electrochemical sensing has revolutionized the electroanalytical detections in the world. Since the 19th century, a huge amount of growth has been visible on various fronts, such as biosensors, energy devices, semiconductor devices, communication, embedded systems, sensors etc. However, the major research gap lies in the fact that most of the reported literatures are bulk systems; hence there are limitations for practical applications. Research in these domains has been carried out by both academia and industry, whereby academics is the backbone whose intellectual outputs have been widely adopted by the industry and implemented for consumers at large. In order to impart portability to the electrochemical sensors for point-of-care application, the collaboration of electrochemistry, microfluidics, electronics and communication as an interdisciplinary forum is crucial. The miniaturization, automation, IoT enabling and integration are the requirements for building the mentioned research gap. The conversion of electrochemical sensing theoretical concepts to practical applications in real time via miniaturization and integration of microfluidics will enhance this domain. In this context, of lately, several research groups have developed miniaturized microdevices as electrochemical-sensing platforms. This has led to a demand of offering a reference book as a guideline for the PhD programs in electrochemistry, MEMS, electronics and communication. Undoubtedly, this will have a huge impact for R&D in industries, public-funded research institutes and academic institutions. The book will provide a single forum to understand the current research trends and future perspectives of various electrochemical sensors and their integration in microfluidic devices, automation and point-of-care testing. For students, the book will become a motivation for them to explore these areas for their career standpoints. For the professionals, the book will become a thought-provoking stage to manoeuvre the next-generation devices/processes for commercialization.