Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research
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Metabolomics and Transcriptomics in Biomarker Discovery: Mass Spectrometric Techniques in Volatilome Research
Metabolites are generated in part during catabolism when the consumed sources of energy undergo biotransformation, energy and metabolites are produced and the latter eliminated from the body. Volatile organic compounds (VOCs), semi-VOCs (SVOCs), etc., can be representatives of the metabolic processes, but also can be generated in pathologic conditions of organisms as signaling agents that transmit potential etiologic information on the disease states of the host. With recent advances in molecular biology and diagnostics, new forms of interdisciplinary science link VOC and SVOC production with genome, transcriptomic and proteomic data sets, and through biomarker discovery, translation and validation coupled with the latest advances in mass spectrometry, they contribute significantly to the emerging area called “volatilome” research. Volatilome research emerges in part from the awareness that organisms emit biomarker VOCs representative of their physiological state, stress conditions, etc., and on the mediating interactions between the host and the environment. For example, human and animal breath contains a vast number of VOCs that translate information about their health, and in case of plants, VOCs can be released in response to an external trigger, such as temperature or osmotic stress, herbivore perturbations, etc. Plant foliar VOCs contribute to potential application in crop stress response, defense, and enhanced biomass production which offers a renewable feedstock for sustainable energy and materials production within a biorefining context. Multi-omics is a valuable tool to investigate the processes involved in the fate of VOCs and their use as potential biomarkers in the inter-species microbiome utilizing the latest technologies in analytical chemistry, such as multidimensional gas or ultra-high performance liquid chromatography coupled with high resolution mass spectrometry.
Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines
Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.
Volatile Organic Compound Analysis in Biomedical Diagnosis Applications
This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer