Metabolic Modulation Of Cellular Function
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Metabolic Modulation of Cellular Function
Metabolic pathways and their metabolites are gaining recognition as both sensitive biomarkers for pathological conditions and key modulators of cell fate. In the past, metabolic changes were considered a consequence of gene expression, metabolite control, or environmental changes such as starvation. However, extensive research in the last decade has demonstrated that metabolic changes respond to and influence cellular signaling. This crosstalk between metabolism and cellular signaling is mainly enabled by novel metabolite-mediated modulation of enzymatic activity of rate-limiting steps and post-translational and epigenetic modifications, for which metabolites serve as substrates.
Thiol Metabolism and Redox Regulation of Cellular Functions
This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place.