Mesenchymal Stem Cell Derived Exosomes
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Mesenchymal Stem Cell Derived Exosomes
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Osteogenesis and Bone Regeneration
Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.
Stem Cell-Derived Exosomes and Microvesicles
This book is an essential resource on the technologies and applications of exosomes and extracellular microvesicles derived from stem cells. Divided into three parts, the book covers the biology of stem cell-derived extracellular vesicles; isolation, characterization, and manufacture of exosomes and extracellular vesicles from stem cells; and exosomes and extracellular vesicle therapy. Taken as a whole, readers will learn how exosomes and extracellular vesicles are produced for clinical use. This is an ideal book for clinical researchers, cell and stem cell scientists, corporate leaders, and scientific entrepreneurs, as well as undergraduate and graduate students studying medicine, the biological sciences, and biotechnology.