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Biological Roles of Sialic Acid
Author: Abraham Rosenberg
language: en
Publisher: Springer Science & Business Media
Release Date: 2013-11-11
There is a startling amount of research activity concerning the role of sialic acid in mammalian cells and in the mammalian organism. One may discern in the early literature premonitions of compounds containing sialic acid, traceable by descriptions of color reactions, as far back as the turn of the century. Work spanning the 1930s to the 1950s culmi nated in the crystallization of sialic acid from a wide variety of biological materials. The ubiquitous nature of the sialic acids, and the biological importance of the substances in which they occur, then became generally manifest. Since then, the chemistry and metabolism of sialic acid and its occurrence, notably, but not exclusively, in the outer cell surfaces of mammalian cells and in key extracellular glycoproteins, have received great attention. The involvement of sialic acid-containing substances in tumorigenicity and in numerous metabolic and infectious pathological conditions, and in the growth, development, and integrity of mammalian cells has achieved widespread recognition. Intensive inquiry into the biological roles of sialic acid continues in a large number of research laboratories throughout the world. This book is intended to represent for the uninitiated as well as for the expert a wide and detailed overview of the current state of knowledge. Major efforts and pioneering break throughs have emerged from several laboratories, located on both sides of the Atlantic, of which we make no special individual mention here since they will to some extent appear in the pages that follow.
Organizational Behavior 6
This is the first comprehensive overview of the development of the field of Organizational Behavior. It belongs on the shelf of every scholar and student in the discipline. Part I covers the foundations of the scientific method, theory development, and the accrual of scientific knowledge in the field. Part II introduces the ideas of pioneers whose work pre-dates the emergence of Organizational Behavior. Part III considers the actual emergence of OB as we know it today, with an analysis of the environmental forces that impinged upon it (such as the recruiting of social scientists into business schools). Part IV presents an assessment of the current state of the art in OB research, with an original assessment of the importance, validity, and practical usefulness of 73 core theories in OB. Finally, Part V sets forth a vision for the future identity and growth of Organizational Behavior research, theory, and practice.
Advances in Biomedical Engineering
Advances in Biomedical Engineering, Volume 6, is a collection of papers that discusses the role of integrated electronics in medical systems and the usage of biological mathematical models in biological systems. Other papers deal with the health care systems, the problems and methods of approach toward rehabilitation, as well as the future of biomedical engineering. One paper discusses the use of system identification as it applies to biological systems to estimate the values of a number of parameters (for example, resistance, diffusion coefficients) by indirect means. More particularly, the indirect approach concerns the application techniques only in the respiratory system. Another paper describes the status of custom integrated electronics in medicine—that significant improvements in the quality, accessibility, and cost of health care can be achieved through innovating their applications in medicine. These integrated electronics include subcutaneous, supercutaneous, percutaneous, transcutaneous, and extracutaneous applications. One paper reviews the excitation and control of skeletal muscle such as in therapeutic electrical stimulation and suppression of undesired movement. An important part of electrical stimulation sensory feedback mechanism which will allow the investigator to have move functional control over the extremities or limbs being tested. The collection can prove valuable to micro-biologists, bio-chemists, physiologists, developmental biologists, and investigators involved in physical rehabilitation and biomaterials research.