Mechanobiology Of Cell Matrix Interactions
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Mechanobiology of Cell-Matrix Interactions
The cell-matrix interaction is a fundamental aspect of cellular biology. It involves the dynamic relationship between cells and the extracellular matrix (ECM). The ECM is a complex network of proteins and polysaccharides that provides structural and biochemical support to surrounding cells. This interaction is crucial for numerous physiological processes, including cell adhesion, migration, proliferation and differentiation. Cells interact with the ECM through specialized receptors, such as integrins, which transmit signals that influence cellular behavior and function. Understanding cell-matrix interactions is pivotal in various fields, including tissue engineering, regenerative medicine, and cancer research. In tissue engineering, mimicking the natural cell-matrix environment is essential for creating functional artificial tissues. Ongoing research in this area promises to unlock new therapeutic strategies for a range of diseases. Cell-matrix interaction is an upcoming field of science that has undergone rapid development over the past few decades.This book includes some of the vital pieces of work being conducted across the world, on various topics related to cell-matrix. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.
Mechanobiology of Cell-Cell and Cell-Matrix Interactions
Author: A. Wagoner Johnson
language: en
Publisher: Springer Science & Business Media
Release Date: 2011-02-21
Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.
Multi-scale Extracellular Matrix Mechanics and Mechanobiology
This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.