Mechanisms Of Epigenetics And Genetics In Leukemogenesis

Mechanisms of Epigenetics and Genetics in Leukemogenesis

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

A Picture of Australia's Children 2012

This report provides updated data on how Australia's children are faring. Statistics are presented against key national indicators of child health, development and wellbeing, including the Children's Headline Indicators. Topics include mortality, disability, breastfeeding, dental health, physical activity, nutrition, early childhood education, transition to school, literacy and numeracy, social and emotional development, teenage births, birth weight, alcohol and tobacco use during pregnancy, family functioning, family economic situation, parental health, non-parental care, neighbourhood safety, social capital, injuries, bullying, child abuse, violence, crime, homelessness, immunisation and screening, child care, and child protection. Though Australian children are doing well in some areas, there is still room for improvement, especially for children from Aboriginal and Torres Strait Islander backgrounds or from socioeconomically disadvantaged areas.