Materials And Strategies For Lab On A Chip
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Materials and Strategies for Lab-on-a-Chip - Biological Analysis, Cell-Material Interfaces and Fluidic Assembly of Nanostructures: Volume 1191
Author: Sashi K. Murthy
language: en
Publisher: Cambridge University Press
Release Date: 2009-11-12
The development of miniaturized systems for chemical and biochemical analysis has grown to the point where lab-on-a-chip devices are now important enabling tools in a diverse array of application areas. As the size of these systems continues to shrink, details of the micro- and nanoscale phenomena associated with their construction and operation must be considered. This book focuses on materials and engineering aspects of lab-on-a-chip devices and the application of microfluidics to materials synthesis. A microfabricated fluidic system integrating biological sample treatment and detection on a single chip offers the promise of low-cost, rapid and high-performance analysis. These devices can perform high-throughput biochemical assays for drug discovery and provide portability for point-of-care diagnostics and biothreat monitoring. Topics include: frontiers in lab-on-a-chip research; materials for lab-on-a-chip; materials synthesis on chip; cell manipulation and biomimetics on chip; porous materials in lab-on-a-chip; sensing and detection on chip - molecular level; sensing and detecting on chip - cells and particles; and sensing and detection on chip - DNA.
Regenerative Medicine Technology
Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.
Lab-on-a-chip Devices for Advanced Biomedicines
Author: Arpana Parihar
language: en
Publisher: Royal Society of Chemistry
Release Date: 2024-08-14
The global miniature devices market is poised to surpass a valuation of $12–$15 billion USD by the year 2030. Lab-on-a-chip (LOC) devices are a vital component of this market. Comprising a network of microchannels, electrical circuits, sensors, and electrodes, LOC is a miniaturized integrated device platform used to streamline day-to-day laboratory functions, run cost-effective clinical analyses and curb the need for centralized instrumentation facilities in remote areas. Compact design, portability, ease of operation, low sample volume, short reaction time, and parallel investigation stand as the pivotal factors driving the widespread acceptance of LOC within the biomedical community. In this book, the Editors meticulously explore LOC through three key ‘Ts’: Theories (microfluidics, microarrays, instrumentation, software); Technologies (additive manufacturing, artificial intelligence, computational thinking, smart consumables, scale-up tactics, and biofouling); and Trends (biomedical analysis, point-of-care diagnostics, personalized healthcare, bioactive synthesis, disease diagnosis, and space applications) This comprehensive text not only provides readers with a thorough understanding of the current advancements in the LOC domain but also offers valuable insights to support the utilization of miniaturized devices for enhanced healthcare practices. Aimed at career researchers looking for instruction in the topic and newcomers to the area, the book is also useful for undergraduate and postgraduate students embarking on new studies or for those interested in reading about the LOC platform.