Mapping Of Monogenic And Quantitative Trait Loci Using A Whole Genome Scan Approach And Single Nucleotide Polymorphism Platforms

Mapping of Monogenic and Quantitative Trait Loci Using a Whole Genome Scan Approach and Single Nucleotide Polymorphism Platforms

Dermatology E-Book

With more complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery than you'll find in any other source, Dermatology, 4th Edition, is the gold-standard reference in the field today. Drs. Jean L. Bolognia, Julie V. Schaffer, and Lorenzo Cerroni bring their considerable knowledge and experience to this two-volume masterwork, ensuring its reliability and usefulness for both residents and practitioners. - Provides the in-depth, expert information you need to address challenges you face in practice across all subspecialties – including medical dermatology, pediatric dermatology, dermatopathology, dermatologic surgery, and cosmetic dermatology. - Uses the famous "easy-in, easy-out" approach, transforming complex information into more than 1,000 reader-friendly tables and algorithms, along with templated chapter contents for quick recognition and access. - Focuses on the essential "need-to-know" basic science information and key references. - Brings together an esteemed team of expert editors and contributors that provide a truly global perspective, led by Drs. Jean L. Bolognia, Julie V. Schaffer, and Lorenzo Cerroni. - Includes over 4,000 illustrations, with over 2,000 new images in this edition, that provide more examples of skin disorders across different skin types in varying stages of presentation; plus enhanced histologic images that provide a clearer understanding of clinicopathologic correlations for multiple skin disorders. - Enhances learning opportunities with 20 new video clips of core procedures, including nail surgery, flaps, grafts, laser therapy, soft tissue augmentation, and botulinum toxin injections, plus 200 bonus online images. - Features 70 brand-new schematics and algorithms to better aid diagnosis, optimize decision making, and improve your approach to each patient. - Includes the latest therapy options with supporting evidence-based grading levels. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Gene Discovery for Disease Models

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).