Machine Learning Frameworks For Data Driven Personalized Clinical Decision Support And The Clinical Impact
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Artificial Intelligence in Healthcare
Artificial Intelligence (AI) in Healthcare is more than a comprehensive introduction to artificial intelligence as a tool in the generation and analysis of healthcare data. The book is split into two sections where the first section describes the current healthcare challenges and the rise of AI in this arena. The ten following chapters are written by specialists in each area, covering the whole healthcare ecosystem. First, the AI applications in drug design and drug development are presented followed by its applications in the field of cancer diagnostics, treatment and medical imaging. Subsequently, the application of AI in medical devices and surgery are covered as well as remote patient monitoring. Finally, the book dives into the topics of security, privacy, information sharing, health insurances and legal aspects of AI in healthcare. - Highlights different data techniques in healthcare data analysis, including machine learning and data mining - Illustrates different applications and challenges across the design, implementation and management of intelligent systems and healthcare data networks - Includes applications and case studies across all areas of AI in healthcare data
Machine Learning Frameworks for Data-Driven Personalized Clinical Decision Support and the Clinical Impact
Disease progression manifests through a broad spectrum of statically and longitudinally linked clinical features and outcomes. This leads to heterogeneous progression patterns that may vary greatly across individual patients and makes the survival and quality of a patient's life substantially different. Recently, the rapid increase of healthcare databases, such as electronic health records (EHRs) and disease registries, has opened new opportunities for "data-driven" approaches to clinical decision support systems. This dissertation addresses the question of how machine learning (ML) techniques can capitalize on these data resources and provide actionable intelligence to move away from a rules-based clinical care toward a more data-driven and personalized model of care. To this end, we develop a set of data-driven ML frameworks that can better predict and understand disease progression under two broad clinical setups: (I) the static setup where patients' observations are collected at a particular point of time and (II) the longitudinal setup where observations of each patient are repeatedly collected over a period of time. In these setups, we focus on building ML methods that are (i) accurate by providing better performance in predicting disease-related outcomes, (ii) automated by freeing clinicians from the concern of choosing one particular model for a given dataset at hand, and (iii) actionable in a sense that the model is capable of answering "what if" questions and discovering subgroups of patients with similar progression patterns and outcomes. We highlight the following technical contributions. In the static setting, we present a set of novel ML algorithms for survival analysis, a framework that informs the relationships between the clinical features and the events of interest (such as death, onset of a certain disease, etc.), and predicts what type of event will occur and when it will occur. We start off by developing a deep learning (DL) method that makes no modeling assumptions about the underlying survival process and that flexibly allows for competing events. Then, we propose an automated ML for survival analysis that combines the collective intelligence of different survival models to produce a valid survival function that is both discriminative and well-calibrated. Lastly, we develop a DL model that can accurately estimate heterogeneous treatment effects in survival analysis by adjusting for covariate shifts from multiple sources which makes the problem unique and challenging. In the longitudinal setting, we first develop a DL model for dynamic survival analysis which provides personalized and event-specific survival predictions based on a patient's heterogeneous and historical context. Then, we provide a novel temporal clustering method that can transform the raw information in the complex longitudinal observations into clinically relevant and interpretable information to recognize future outcomes as well as life-changing disease manifestations which may cause a patient to transit between clusters. To show the utilities of the proposed models, we evaluate the performance on various real-world medical datasets on breast cancer, prostate cancer, and cystic fibrosis patient cohorts. We demonstrate that the proposed models consistently outperform clinical scores and state-of-the-art ML methods in predicting disease progression, estimating the heterogeneous treatment effects, and providing insights into underlying disease mechanisms.
Data-Driven Clinical Decision-Making Using Deep Learning in Imaging
This book explores cutting-edge medical imaging advancements and their applications in clinical decision-making. The book contains various topics, methodologies, and applications, providing readers with a comprehensive understanding of the field's current state and prospects. It begins with exploring domain adaptation in medical imaging and evaluating the effectiveness of transfer learning to overcome challenges associated with limited labeled data. The subsequent chapters delve into specific applications, such as improving kidney lesion classification in CT scans, elevating breast cancer research through attention-based U-Net architecture for segmentation and classifying brain MRI images for neurological disorders. Furthermore, the book addresses the development of multimodal machine learning models for brain tumor prognosis, the identification of unique dermatological signatures using deep transfer learning, and the utilization of generative adversarial networks to enhance breast cancer detection systems by augmenting mammogram images. Additionally, the authors present a privacy-preserving approach for breast cancer risk prediction using federated learning, ensuring the confidentiality and security of sensitive patient data. This book brings together a global network of experts from various corners of the world, reflecting the truly international nature of its research.