Lymphatic System Functions
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Capillary Fluid Exchange
Author: Joshua Scallan
language: en
Publisher: Morgan & Claypool Publishers
Release Date: 2010
The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
Peripheral Lymphedema
This book provides extensive knowledge of peripheral lymphedema, including the etiology and pathophysiology of the disease, as well as the anatomy and physiology of the lymphatic system and guide for the treatment of lymphedema to clinicians. The ultimate goal of lymphedema therapy is the targeted and individualized treatment. New technology of multimodality lymphatic imaging emerged in the recent years largely improves the diagnosis of lymphatic circulation disorders. The treatment of peripheral lymphedema is expected to have new achievement. This book illustrates the latest achievements in clinical and basic research of lymphedema to the clinical investigators as well as basic researchers. Pathogenesis of lymphatic system, diagnosis of lymphedema, treatment and further complication management are demonstrated in this book. Some special lymphedema related syndromes, issues on prevention and prognosis are also included.
Vascular Biology of the Placenta
Author: Yuping Wang (MD.)
language: en
Publisher: Morgan & Claypool Publishers
Release Date: 2010
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.