Lucia S Progress

Sustainable Ocean Governance

This topical book examines ocean governance and calls for close co-operation between science and policy. Adalberto Vallega uniquely considers the ocean as a spatial complex system which must be represented as a whole and argues that scientific approaches must change to achieve progress and co-operation between science and policy.

Advances in precision diagnosis and therapy of pediatric rare diseases

Metastatic Progression and Tumour Heterogeneity

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.