Lethal Theory

THEORIES OF SUICIDE

Some researchers in the field of suicidology think that the old theories of suicide are too constraining and impede advances in the understanding of suicide. However the book’s authors are not quite so critical of past theories. In the book they review the classic theories of suicide, both psychological and sociological, because they are the foundation of our current theories and also propose the skeletons of possible future theories. The goal of the text is to present researchers with theories to guide their research, encourage them to modify these theories, perhaps meld them together in some cases, and think how they might propose new theories. Presented in three sections, the first reviews significant psychological theories including: Suicide as Escape; Interpersonal-Psychological theory; The Role of Defeat and Entrapment in Suicidal Behavior; Suicide, Ethology and Sociobiology; Stress-Diatheses; Cognitive Theories; Learning Perspective on Suicide; Theories of Personality and Suicide; Typological Theories; and the Pathophysiology of Suicide. The second section of the text addresses Sociological and Economic Theories including: Suicide as Deviance, Naroll’s Thwarting Disorientation Theory, three classic sociological theories as well as several minor theories. A comprehensive chapter on economic theories is offered by Bijou Yang. The final section concentrates on Critical Thoughts About Theories of Suicide, a new and growing influence in academia and scholarship.

UCRL.

Quasispecies: From Theory to Experimental Systems

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.