Horizon In Frontotemporal Lobar Degeneration Related Disorder

Horizon in Frontotemporal Lobar Degeneration Related Disorder

Frontotemporal lobar degeneration (FTLD) encompasses a spectrum of focal neurodegenerative disorders with progressive atrophy of the frontal and temporal lobes. FTLD-related disorders are heterogeneous clinical conditions characterized by social dysfunction and personality changes as well as impairments in language, executive and motor functions. Current clinical diagnostic criteria characterize specific manifestations of FTLD, including transtemporal behavioral dementia (bvFTD), primary progressive aphasia with agrammatic variant (avPPA) and semantic variant (svPPA) subtypes, and movement disorders, including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and FTD with amyotrophic lateral sclerosis (FTD-ALS).

Neurodegenerative Diseases

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease

Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis: Genetics, Clinical and Pathological Features, and Disease Mechanisms